O-GlcNAc signaling: a metabolic link between diabetes and cancer?

Abstract

O-linked β-N-acetylglucosamine (O-GlcNAc) is a sugar attachment to serine or threonine hydroxyl moieties on nuclear and cytoplasmic proteins. In many ways, O-GlcNAcylation is similar to phosphorylation because both post-translational modifications cycle rapidly in response to internal or environmental cues. O-GlcNAcylated proteins are involved in… (More)
DOI: 10.1016/j.tibs.2010.04.005

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