O-Antigen modifications providing antigenic diversity of Shigella flexneri and underlying genetic mechanisms

@article{Knirel2015OAntigenMP,
  title={O-Antigen modifications providing antigenic diversity of Shigella flexneri and underlying genetic mechanisms},
  author={Yuriy A. Knirel and Qiang-zheng Sun and Sof’ya N. Senchenkova and Andrei V. Perepelov and Alexander S. Shashkov and Jianguo Xu},
  journal={Biochemistry (Moscow)},
  year={2015},
  volume={80},
  pages={901-914}
}
O-Antigens (O-specific polysaccharides) of Shigella flexneri, a primary cause of shigellosis, are distinguished by a wide diversity of chemical modifications following the oligosaccharide O-unit assembly. The present review is devoted to structural, serological, and genetic aspects of these modifications, including O-acetylation and phosphorylation with phosphoethanolamine that have been identified recently. The modifications confer the host with specific immunodeterminants (O-factors or O… Expand
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