O-Acylation of Substituted Phenols with Various Alkanoyl Chlorides Under Phase-Transfer Catalyst Conditions

  title={O-Acylation of Substituted Phenols with Various Alkanoyl Chlorides Under Phase-Transfer Catalyst Conditions},
  author={Alina Marieta Simion and Iwao Hashimoto and Yoshiharu Mitoma and Naoyoshi Egashira and Cristian Ovidiu Simion},
  journal={Synthetic Communications},
  pages={921 - 931}
Abstract Esterification of several types of mono- and disubstituted phenols with various mono- and dialkanoyl chlorides was performed in phase-transfer catalysis conditions, using tetrabutylammonium chloride in a mixture of aqueous NaOH and dichloromethane. The process is particularly efficient (almost quantitative yields) as well as rapid (only 5 min reaction time, at a temperature of 0 °C). GRAPHICAL ABSTRACT 
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