O-Acetylation of the terminal N-acetylglucosamine of the lipooligosaccharide inner core in Neisseria meningitidis. Influence on inner core structure and assembly.

@article{Kahler2006OAcetylationOT,
  title={O-Acetylation of the terminal N-acetylglucosamine of the lipooligosaccharide inner core in Neisseria meningitidis. Influence on inner core structure and assembly.},
  author={Charlene M Kahler and Shauna Lyons-Schindler and Biswa Pronab Choudhury and John G. Glushka and Russell W Carlson and David S. Stephens},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 29},
  pages={19939-48}
}
O-Acetylation is a common decoration on endotoxins derived from many Gram-negative bacterial species, and it has been shown to be instrumental (e.g. in Salmonella typhimurium) in determining the final tertiary structure of the endotoxin and the immunogenicity of the molecule. Structural heterogeneity of endotoxins produced by mucosal pathogens such as Neisseria meningitidis is determined by decorations on the heptose inner core, including O-acetylation of the terminal N-acetylglucosamine… CONTINUE READING

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