O(6)-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications.

@article{Brandes2010O6methylguanineDM,
  title={O(6)-methylguanine DNA-methyltransferase methylation status can change between first surgery for newly diagnosed glioblastoma and second surgery for recurrence: clinical implications.},
  author={Alba A Brandes and Enrico Franceschi and Alicia Tosoni and Stefania Bartolini and Antonella Bacci and Raffaele Agati and Claudio Ghimenton and Sergio Turazzi and Andrea Talacchi and Miran Skrap and Gianluca Marucci and Lorenzo Volpin and Luca Morandi and Stefano Pizzolitto and Marina Paolo Gardiman and Alvaro Andreoli and Fabio Calbucci and M. Ermani},
  journal={Neuro-oncology},
  year={2010},
  volume={12 3},
  pages={283-8}
}
O(6)-methylguanine DNA-methyltransferase (MGMT) promoter methylation status is a prognostic factor in newly diagnosed glioblastoma patients. However, it is not yet clear whether, and if so how, MGMT methylation status may change. Moreover, it is unknown whether the prognostic role of this epigenetic feature is retained during the disease course. A retrospective analysis was made using a database of 614 glioblastoma patients treated prospectively from January 2000 to August 2008. We evaluated… CONTINUE READING
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