Nyctohemeral changes in bone turnover assessed by serum bone Gla-protein concentration and urinary deoxypyridinoline excretion: effects of growth and ageing.

@article{Eastell1992NyctohemeralCI,
  title={Nyctohemeral changes in bone turnover assessed by serum bone Gla-protein concentration and urinary deoxypyridinoline excretion: effects of growth and ageing.},
  author={Richard Eastell and Patricia S Simmons and Amy S. Colwell and A. M. A. Assiri and Mary F. Burritt and R. Graham G. Russell and B. Lawrence Riggs},
  journal={Clinical science},
  year={1992},
  volume={83 3},
  pages={375-82}
}
1. To investigate whether there is a nyctohemeral rhythm in bone turnover, we measured serum bone Gla-protein (osteocalcin, an index of osteoblast activity) concentration every 2h and urinary deoxypyridinoline (a marker of bone collagen resorption) excretion for 8h periods in 10 pubertal girls (aged 10-14 years), 15 premenopausal women (aged 20-49 years) and 17 postmenopausal women (aged 50-75 years). 2. The serum concentration of bone Gla-protein and the urinary excretion of deoxypyridinoline… CONTINUE READING