Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete X-linked congenital stationary night blindness.

@article{Gregg2007NyctalopinEI,
  title={Nyctalopin expression in retinal bipolar cells restores visual function in a mouse model of complete X-linked congenital stationary night blindness.},
  author={Ronald G Gregg and Maarten Kamermans and J. van't Klooster and Peter D. Lukasiewicz and Neal S Peachey and Kirstan A Vessey and Maureen A. McCall},
  journal={Journal of neurophysiology},
  year={2007},
  volume={98 5},
  pages={3023-33}
}
Mutations in the NYX gene that encodes the protein nyctalopin cause congenital stationary night blindness type 1. In no b-wave (nob) mice, a mutation in Nyx results in a functional phenotype that includes the absence of the electroretinogram b-wave and abnormal spontaneous and light-evoked activity in retinal ganglion cells (RGCs). In contrast, there is no morphological abnormality in the retina at either the light or electron microscopic levels. These functional deficits suggest that… CONTINUE READING

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