Nuts and bolts of psychiatric genetics: building on the Human Genome Project.

  title={Nuts and bolts of psychiatric genetics: building on the Human Genome Project.},
  author={Kathryn L. Evans and Walter J. Muir and Douglas H R Blackwood and David J. Porteous},
  journal={Trends in genetics : TIG},
  volume={17 1},
Schizophrenia and bipolar affective disorder are chronic, disabling illnesses that together affect 2% of the population. Genetic factors are known to be important in their development, but there are, as yet, no confirmed susceptibility genes. Here we discuss important issues in terms of alternative genetic strategies (linkage, association and/or cytogenetics) in the identification of candidate genes for the major psychoses. We discuss the impact of the Human Genome Project, the role of… CONTINUE READING
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