Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide.

@article{Osanai2017NutritionalRO,
  title={Nutritional regulation of coupling factor 6, a novel vasoactive and proatherogenic peptide.},
  author={Tomohiro Osanai and Kasumi Mikami and Maiko Kitajima and Mayumi Urushizaka and Kumiko Kawasaki and Toshiko Tomisawa and Chieko Itaki and Yuka Noto and Koji Magota and Hirofumi Tomita},
  journal={Nutrition},
  year={2017},
  volume={37},
  pages={74-78}
}
High sodium, high glucose, and obesity are important risk factors for age-related diseases such as cardiovascular disease (CVDs), stroke, and cancer. Coupling factor 6 (CF6) is released from vascular endothelial cells and functions as a circulating peptide that inhibits prostacyclin and nitric oxide generation by intracellular acidosis. High glucose elevates CF6 by activation of protein kinase C and p38 mitogen-activated protein kinase, whereas CF6 causes type 2 diabetes mellitus, resulting in… CONTINUE READING