Nutritional psychiatry: the present state of the evidence

  title={Nutritional psychiatry: the present state of the evidence},
  author={Wolfgang Marx and Genevieve Moseley and Michael Berk and Felice Nellie Jacka},
  journal={Proceedings of the Nutrition Society},
  pages={427 - 436}
Mental illness, including depression, anxiety and bipolar disorder, accounts for a significant proportion of global disability and poses a substantial social, economic and heath burden. Treatment is presently dominated by pharmacotherapy, such as antidepressants, and psychotherapy, such as cognitive behavioural therapy; however, such treatments avert less than half of the disease burden, suggesting that additional strategies are needed to prevent and treat mental disorders. There are now… 

Diet and Depression: From Epidemiology to Novel Therapeutics

Diet and depression: exploring the biological mechanisms of action

The nascent nature of the nutritional psychiatry field to date means that the existing literature identified is largely comprised of preclinical animal studies, and intervention studies that assess markers related to these pathways within clinically diagnosed human populations are needed.

Nutritional psychiatry: Towards improving mental health by what you eat

Nutrition-based interventions for mood disorders

Nutritional Psychiatry is an emerging area of research that has great potential as an adjunctive tool for the prevention and treatment of diverse neuropsychiatric disorders and nutrition-based strategies for gut microbiota modulation are promising fields in mood disorders.

Nutritional Psychiatry: Connecting Depression and Heart Failure with The Science of Nutrition

The emerging evidence from Nutrition shows relevant factors in the high prevalence of mental disorders, suggesting that diet is as important for Psychiatry as for Cardiology and Endocrinology.

Nutrition and Depression

Long-term and large-cohort research is required to reveal different mechanisms and to fully understand the relationship between nutrition and depression.

Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies

To conclude, adhering to a healthy diet, in particular a traditional Mediterranean diet, or avoiding a pro-inflammatory diet appears to confer some protection against depression in observational studies, which provides a reasonable evidence base to assess the role of dietary interventions to prevent depression.

Nutrition, nutritional deficiencies, and schizophrenia: An association worthy of constant reassessment

Examination of existing scientific literature dealing with the possible relationship between nutrition and schizophrenia is examined, with a view to elucidating the impact of diet, nutritional deficiencies and excesses on the aetiology, progression, management and outcome of schizophrenia.

Association Between Dietary Habits and Depression: A Systematic Review

Depression being the psychiatric condition with the highest societal costs in industrialized nations, it is necessary to collect research information on the role of nutrition in depression in order

The Mediterranean diet and depression – can a healthier dietary pattern reduce the risk of depression?

An overview of the problem of depression in the UK, the origins and features of the MedDiet and current state of research into its effects on mental health are provided, as well as a detailed discussion of the study by Lassale et al.



Nutritional Psychiatry: Where to Next?

  • F. Jacka
  • Psychology, Medicine
  • 2017

Nutritional Factors Affecting Mental Health

The aims of this review are to introduce known nutritional factors for mental health, and to discuss recent issues of the nutritional impact on cognitive function and healthy brain aging.

Major depressive disorder and nutritional medicine: a review of monotherapies and adjuvant treatments.

A literature review was conducted to examine the evidence for nutritional interventions in depression and found that more positive clinical trials were found to support adjuvant, rather than monotherapeutic, use of nutrients to treat depression.

The impact of whole-of-diet interventions on depression and anxiety: a systematic review of randomised controlled trials

Some evidence for dietary interventions improving depression outcomes is found, however, as only one trial specifically investigated the impact of a dietary intervention in individuals with clinical depression, appropriately powered trials that examine the effects of dietary improvement on mental health outcomes in those with clinical disorders are required.

The effects of probiotics on depressive symptoms in humans: a systematic review

The evidence for probiotics alleviating depressive symptoms is compelling but additional double-blind randomized control trials in clinical populations are warranted to further assess efficacy.

Broad-spectrum micronutrient formulas for the treatment of psychiatric symptoms: a systematic review

Despite positive preliminary findings, there are less data available to support efficacy of micronutrient formulas in treating bipolar disorder, attention deficit-hyperactivity disorder and substance abuse/dependence and no clinical trials have been done with clinically depressed or anxious patient samples, psychosis or eating disorders.

Diet and Common Mental Disorders: The Imperative to Translate Evidence into Action

This paper argues the necessity of translating the new knowledge regarding the diet–depression paradigm into the development and implementation of public health and clinical intervention strategies at a population level.

Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review

The effects of vitamin and mineral supplementation on symptoms of schizophrenia: a systematic review and meta-analysis

Preliminary evidence is needed to examine how the benefits of supplementation relate to nutrient deficits and the impact upon underlying neurobiological pathways, in order to establish optimal nutrient formulations for improving clinical outcomes in this population of schizophrenia.

Design and rationale of a 16-week adjunctive randomized placebo-controlled trial of mitochondrial agents for the treatment of bipolar depression.

This study may provide a novel adjunctive treatment for bipolar depression by exploring the potential benefits of N-acetylcysteine alone or in combination with selected nutraceuticals believed to enhance mitochondrial function.