Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions

@article{Lafourcade2011NutritionalOD,
  title={Nutritional omega-3 deficiency abolishes endocannabinoid-mediated neuronal functions},
  author={Mathieu Lafourcade and Thomas Larrieu and Susana Mato and Anais Duffaud and Marja D Sepers and Isabelle Matias and V{\'e}ronique De Smedt-Peyrusse and Virginie F. Labrousse and Lionel Br{\'e}tillon and Carlos Matute and Rafael Rodr{\'i}guez-Puertas and Sophie Lay{\'e} and Olivier J Manzoni},
  journal={Nature Neuroscience},
  year={2011},
  volume={14},
  pages={345-350}
}
The corollaries of the obesity epidemic that plagues developed societies are malnutrition and resulting biochemical imbalances. Low levels of essential n-3 polyunsaturated fatty acids (n-3 PUFAs) have been linked to neuropsychiatric diseases, but the underlying synaptic alterations are mostly unknown. We found that lifelong n-3 PUFAs dietary insufficiency specifically ablates long-term synaptic depression mediated by endocannabinoids in the prelimbic prefrontal cortex and accumbens. In n-3… CONTINUE READING
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