Nutritional management of rheumatoid arthritis: a review of the evidence.

  title={Nutritional management of rheumatoid arthritis: a review of the evidence.},
  author={Kirsten L Rennie and Janie Hughes and R Lang and Susan A. Jebb},
  journal={Journal of human nutrition and dietetics : the official journal of the British Dietetic Association},
  volume={16 2},
  • K. Rennie, J. Hughes, S. Jebb
  • Published 1 April 2003
  • Medicine
  • Journal of human nutrition and dietetics : the official journal of the British Dietetic Association
Rheumatoid arthritis (RA) is a debilitating disease and is associated with increased risk of cardiovascular disease and osteoporosis. Poor nutrient status in RA patients has been reported and some drug therapies, such as nonsteroidal anti-inflammatory drugs (NSAIDs), prescribed to alleviate RA symptoms, may increase the requirement for some nutrients and reduce their absorption. This paper reviews the scientific evidence for the role of diet and nutrient supplementation in the management of RA… 
Micronutrients Deficiencies in Rheumatoid Arthritis Patients
The scientific evidence for the role of diet and nutrient supplementation in the management of RA, by alleviating symptoms or decreasing progression of the disease is reviewed.
In conclusion, patients with RA should follow antioxidant-rich diet (grains, fruits, vegetables) rather than take vitamin supplementation, and convincing evidence exist that Mediterranean diet, rich in antioxidants, may reduce inflammatory activity, increase physical functioning and improve general well-being.
Dietary interventions with or without omega-3 supplementation for the management of rheumatoid arthritis: a systematic review protocol
The effects of dietary interventions with and without omega-3 supplementation for the management of rheumatoid arthritis are discussed, including measures of disease activity, inflammation and quality of life among adults living with RA.
Nutraceutical Therapies for Degenerative Joint Diseases: A Critical Review
There is growing recognition of the importance of nutritional factors in the maintenance of bone and joint health, and that nutritional imbalance combined with endocrine abnormalities may be involved
Dietary Interventions with or without Omega-3 Supplementation for the Management of Rheumatoid Arthritis: A Systematic Review
Dietary interventions with an anti-inflammatory basis may be an effective way for adults with RA seeking complementary treatments, potentially leading to improvements in certain parameters, however, there is a need for longer duration studies that are well-designed and sufficiently powered to investigate the influence of diet on RA.
Natural anti-inflammatory agents for the management of osteoarthritis
[Role of omega-3 polyunsaturated fatty acids in diet of patients with rheumatic diseases].
The encouraging results of dietetic therapy based on omega-3 in RA are leading researchers to test their effectiveness on patients with other rheumatic conditions such as systemic lupus erythematosus and ankylosing spondylitis.
Nutritional Interventions to Prevent and Treat Osteoarthritis. Part I: Focus on Fatty Acids and Macronutrients
  • H. Lopez
  • Medicine
    PM & R : the journal of injury, function, and rehabilitation
  • 2012
The Evaluation Of Concurrent Supplementation With Vitamin E And Omega- 3 Fatty Acids On Plasma Lipid Per Oxidation And Antioxidant Levels In Patients With Rheumatoid Arthritis
Omega-3 and vitamin E supplements in the prescribed doses did not show any beneficial effect on clinical outcomes of the patients or activity of antioxidant enzymes, however adding vitamin E supplement to omega 3 fatty acid supplements could reduced MDA levels comparing to omega3 fatty acids alone or placebo.
Traditional and modern management strategies for rheumatoid arthritis.


n-3 fatty acid supplements in rheumatoid arthritis.
  • J. Kremer
  • Medicine
    The American journal of clinical nutrition
  • 2000
It appears that a minimum daily dose of 3 g eicosapentaenoic and docosahexaenoic acids is necessary to derive the expected benefits of n-3 fatty acids in patients with rheumatoid arthritis.
Calcium and Vitamin D3 Supplementation Prevents Bone Loss in the Spine Secondary to Low-Dose Corticosteroids in Patients with Rheumatoid Arthritis
It was found that calcium and vitamin D3 prevented substantial loss of bone mineral density in a similar group of patients starting corticosteroid treatment.
Supplementation with Folic Acid during Methotrexate Therapy for Rheumatoid Arthritis: A Double-Blind, Placebo-Controlled Trial
A larger and longer study to evaluate different doses of folic acid, assuming that toxicity could be reduced without changing the efficacy of methotrexate, and the influence of the folic Acid dose on metotrexate toxicity and efficacy remains controversial.
Diet therapy for rheumatoid arthritis.
The study failed to provide evidence of objective overall clinical benefit of this diet as followed by a group of patients with longstanding, progressive, active RA, but the data are not inconsistent with the possibility that individualized dietary manipulations might be beneficial for selected patients with rheumatic disease.
Diets, dietary supplements, and nutritional therapies in rheumatic diseases.
Treatment of Rheumatoid Arthritis with Gammalinolenic Acid
A 24-week, randomized, double-blind comparison of gammalinolenic acid to placebo in patients with rheumatoid arthritis and with active synovitis suggests that enrichment of cells with dihomogammalinorenic acid by administration of glammable acid may be a worthwhile strategy for the control of inflammation.
Review of dietary therapy for rheumatoid arthritis.
There are now sufficient good scientific studies, from the UK and abroad, to suggest that, at least in some patients with RA, dietary therapy may influence at least the symptoms and possibly the
Folic acid and folinic acid for reducing side effects in patients receiving methotrexate for rheumatoid arthritis.
The results support the protective effect of folate supplementation in reducing MTX side effects related to the oral and GI systems and suggest folinic acid must be found more effective than folic acid at reducing MTx side effects to be considered cost-effective.
Vitamin D and calcium in the prevention of corticosteroid induced osteoporosis: a 3 year followup.
Vitamin D and calcium may help prevent the early loss of bone seen in the lumbar spine as measured by densitometry of the lumbo spine in those undergoing extended therapy with corticosteroid treated subjects.