Nutritional interventions for autism spectrum disorder.
@article{Karhu2019NutritionalIF, title={Nutritional interventions for autism spectrum disorder.}, author={Elisa Karhu and Ryan Zukerman and Rebecca S. Eshraghi and Jeenu Mittal and Richard Carlton Deth and Ana M. Castejon and Malav S Trivedi and Rahul Mittal and Adrien A. Eshraghi}, journal={Nutrition reviews}, year={2019} }
Autism spectrum disorder (ASD) is an increasingly prevalent neurodevelopmental disorder with considerable clinical heterogeneity. With no cure for the disorder, treatments commonly center around speech and behavioral therapies to improve the characteristic social, behavioral, and communicative symptoms of ASD. Gastrointestinal disturbances are commonly encountered comorbidities that are thought to be not only another symptom of ASD but to also play an active role in modulating the expression of…
38 Citations
A Review of the Efficacy of the Dietary Intervention in Autism Spectrum Disorder
- Medicine, Psychology
- 2021
There is little evidence to support the use of dietary interventions for children with ASD, and further research is needed to provide up-to-date evidence.
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- Medicine, Psychology
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Each individual’s developmental needs and entire dietary patterns should be carefully considered for the elimination of comorbid health conditions, and future research should further explore gluten/casein-free and other restrictive diets, along with the clarification of effective randomized controlled trials.
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The development of targeted medicines for subgroups of ASD has led to numerous recent successes in patients, as reported here.
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- Psychology, Medicine
- 2021
The effects of nutritional diets on ASD are discussed and whether nutrition (Mediterranean diet, gluten-free/casein-free diet, ketogenic diet, special carbohydrate diet, low oxalate diet) is a part of existing treatment in ASD and its beneficial effects are examined.
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It is demonstrated that higher frequency of GI symptoms, food selectivity, and mealtime problems are a common problem in pre-schoolers, schoolchildren, and adolescents with ASD, and together with dietary modification, they are significantly associated with ASD.
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Based on the data obtained during clinical and experimental researches, a hypothesis about the possible role of the purinergic system in the pathogenesis of autism spectrum disorder is considered and results are encouraging, but further research is required.
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The modulation of the gut microbiota in ASD individuals with GI disturbances seems a promising target for the future medicine, and a standardization of the research strategies for large-scale studies together with a focus on poorly explored fields is necessary to strengthen this hypothesis.
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The results of a meta-analysis suggest that diet therapies can significantly ameliorate core symptoms of ASD, and GFD diets are conducive to improving social behaviors.
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The need to assess the DPs and nutrient intakes of children with ASD to correct their alterations and discard some potential nutritional diseases is emphasized.
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