Nutritional infantile vitamin B12 deficiency: pathobiochemical considerations in seven patients.

@article{Roschitz2005NutritionalIV,
  title={Nutritional infantile vitamin B12 deficiency: pathobiochemical considerations in seven patients.},
  author={Birgit Roschitz and Barbara R Plecko and Martina Huemer and Ariane Biebl and Holger F{\"o}rster and Wolfgang Sperl},
  journal={Archives of disease in childhood. Fetal and neonatal edition},
  year={2005},
  volume={90 3},
  pages={F281-2}
}
In infants with nutritional vitamin B12 deficiency, early clinical symptoms follow a consistent pattern with irritability, failure to thrive, apathy and anorexia, accompanied by consistent refusal of solid foods and developmental regression. Vitamin B12 acts as a cofactor in the remethylation of homocysteine and the degradation of methylmalonylCoA. The biochemical mechanisms by which vitamin B12 deficiency leads to neurological damage are poorly understood. We report on seven breast fed infants… CONTINUE READING
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