Nutritional deficiencies in iron overloaded patients with hemoglobinopathies.

  title={Nutritional deficiencies in iron overloaded patients with hemoglobinopathies.},
  author={Susan Claster and John C. Wood and Leila Noetzli and Susan M Carson and Thomas C. Hofstra and Rachna Khanna and Thomas D. Coates},
  journal={American journal of hematology},
  volume={84 6},
One of the hallmarks of both sickle cell disease (SCD) and thalassemia major (TM) is accelerated oxidative damage. Decreased antioxidant levels and increased oxidant stress biomarkers are found in both diseases. Although isolated vitamin deficiencies have been reported in TM and nontransfused SCD patients, a comprehensive evaluation of vitamin and trace mineral levels has never been performed in chronically transfused SCD or TM patients. As vitamins and trace minerals may be consumed as a… CONTINUE READING
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