Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep.

@article{Poore2007NutritionalCD,
  title={Nutritional challenges during development induce sex-specific changes in glucose homeostasis in the adult sheep.},
  author={Kirsten R. Poore and Jane K Cleal and James P Newman and Julian P Boullin and David E Noakes and Mark A. Hanson and Lucy Green},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2007},
  volume={292 1},
  pages={E32-9}
}
The early-life environment has implications for risk of adult-onset diseases, such as glucose intolerance, insulin insensitivity, and obesity, effects that may occur with or without reduced birth weight. We determined the consequences of nutrient restriction in early gestation and early postnatal life and their interactions on postnatal growth, body composition, and glucose handling. Ewes received 100% (C, n = 39) or 50% nutritional requirements (U, n = 41) from 1 to 31 days gestation and 100… CONTINUE READING
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