Nutritional and insulin regulation of leptin gene expression.

  • Nobuko Iritani
  • Published 2000 in
    Current opinion in clinical nutrition and…


The leptin and lipogenic enzyme genes contain the common DNA sequences of binding sites for Sp1 proteins. These sites appear to be responsible for glucose/insulin stimulation and polyunsaturated fatty acid suppression. In rat adipose tissue leptin and lipogenic gene expression is similarly regulated by nutritional manipulation. Interestingly, leptin has the… (More)


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