Nutritional and hormonal control of skeletal-muscle cell growth and differentiation.

  title={Nutritional and hormonal control of skeletal-muscle cell growth and differentiation.},
  author={John Michael Brameld and Peter J Buttery and Jane Dawson and Jean M. Harper},
  journal={The Proceedings of the Nutrition Society},
  volume={57 2},
The growth of muscle involves increases in both cell number (hyperplasia) and cell size (hypertrophy). Hyperplasia involves the mononucleate muscle precursor cells (myoblasts), which subsequently align and fuse (differentiate) to form the multinucleate muscle fibres. This is the stage at which increases in cell size take place (Fig. 1). The present review will concentrate on the control of myoblast proliferation and differentiation, but will also mention the control of muscle fibre size. The… CONTINUE READING


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