Nutritional Intervention With Omega-3 Fatty Acids in a Case of Malignant Fibrous Histiocytoma of the Lungs

  title={Nutritional Intervention With Omega-3 Fatty Acids in a Case of Malignant Fibrous Histiocytoma of the Lungs},
  author={Ronald S. Pardini and David Wilson and Steven Schiff and Stephen A. Bajo and Randall Pierce},
  journal={Nutrition and Cancer},
  pages={121 - 129}
Abstract: We present a case of a 78-yr-old man with malignant fibrous histiocytoma with multiple lesions in both lungs. Following diagnosis, he declined conventional chemotherapy and elected nutritional intervention by increasing intake of omega-3 fatty acids and lowering intake of omega-6 fatty acids. We estimated that he consumed 15 g of the long-chain omega-3 fatty acids eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) per day, and the ratio of linoleic acid/long-chain omega-3 fatty… 

Omega 3 Fatty Acid Recommendations in the American Diet

With cancer as the second leading disease killer in the United States, this review aimed to investigate the effect of omega 3 fatty acids on cancer risk and tumor growth as well as evaluate

Omega‐3 Polyunsaturated Fatty Acids and Lung Cancer: nutrition or Pharmacology?

Omega-3 polyunsaturated fatty acid supplements for chemoprevention of different types of cancer including lung cancer has been investigated in recent years and ω-3 PUFAs are suggested to modulate pivotal pathways underlying the progression or complications of lung cancer, indicating that this is a promising field to be explored.

ω-3 PUFAs and Other Cancers

By understanding the mechanisms of anticancer action of ω-3 PUFAs in pancreatic cancer, lung cancer, skin cancer, cholangiocarcinoma, and leukemia, this chapter will be able to recommend the utilization of �ω-3PUFAs, alone or in combination with standard anticancer drugs, as an effective and safe therapeutic approach for the chemoprevention and treatment of these human cancers.

Shrimp Lipids: A Source of Cancer Chemopreventive Compounds

The purpose of this review is to lay groundwork for future research about the properties of the lipid fraction of shrimp, which has been extensively studied for chemopreventive properties.

Docosahexanoic acid induces dose dependent cell death in an early undifferentiated subtype of acute myeloid leukemia cell line

DHA’s effect on the primitive and undifferentiated AML cell line KG1a is investigated, to explore the potential of this fatty acid in treating acute myeloid leukemia.

Docosahexaenoic acid induces apoptosis in lung cancer cells by increasing MKP-1 and down-regulating p-ERK1/2 and p-p38 expression

The data provide evidence that the DHA-induced overexpression of MKP-1 and the resulting decrease of MAP-kinase phosphorylation by DHA may underlie the pro-apoptotic effect of this fatty acid in lung cancer cells, and support the hypothesis that DHA might exert chemopreventive action in Lung cancer.

Docosahexaenoic Acid-mediated Inhibition of Heat Shock Protein 90-p23 Chaperone Complex and Downstream Client Proteins in Lung and Breast Cancer

A role for dietary intervention to improve cancer therapy in tumors overexpressing Hsp90 and its client proteins is supported, and results were observed when employing 2-deoxyglucose (2-DG), confirming that DHA and 2-G, both independently and combined, can disturb HSp90 molecular chaperone function.

The Growth and Plankton Changes of Intensive Ecological AquacultureModel of Pseudosciaena crocea

The growth of Pseudosciaena crocea and changes of plankton was studied under intensive ecological aquacul- ture model that didn't change water, and the zooplankton was in an equilibrium state.



Dietary polyunsaturated fatty acids and cancers of the breast and colorectum: emerging evidence for their role as risk modifiers.

Current evidence from experimental and human studies is summarized that implicates a high intake of omega-6 PUFAs in cancer of the breast, colon and, possibly, prostate and which indicates that omega-3PUFAs and monounsaturated fatty acids such as oleic acid (omega-9) are protective.

Docosahexaenoic acid ingestion inhibits natural killer cell activity and production of inflammatory mediators in young healthy men

The results show that inhibitory effects of DHA on immune cell functions varied with the cell type, and that the inhibitoryeffects are not mediated through increased production of PGE2 and LTB4.

The effects of dietary omega-3 fatty acids on the DU-145 transplantable human prostatic tumor.

Results are consistent with a role for omega-3 fatty acids in the inhibition of growth of human prostatic tumor cells in nude mice by dietary modification.

n-3 fatty acids decrease colonic epithelial cell proliferation in high-risk bowel mucosa

It is suggested that n-3 fatty acid may be a useful chemopreventive agent in some patients as reflected in a plasma biomarker of colon tumor growth and metastasis and a nutritional marker associated with colonic epithelial cell hyperproliferation in the n- 3-supplemented group as compared with the placebo group.

The effect of dietary docosahexaenoic acid on platelet function, platelet fatty acid composition, and blood coagulation in humans

The results from this study on blood clotting parameters and in vitro platelet aggregation suggest that adding 6 g/d of dietary DHA for 90 d to a typical Western diet containing less than 50 mg/D of DHA produces no observable physiological changes in blood coagulation, platelet function, or thrombotic tendencies in healthy, adult males.

The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension.

The data indicate that high doses of fish oil can reduce blood pressure in men with essential hypertension, however, the clinical usefulness and safety ofFish oil in the treatment of hypertension will require further study.

Inhibitory effects of docosahexaenoic acid on colon carcinoma 26 metastasis to the lung.

Results indicate that uptake of DHA into tumour cells results in altered tumour cell membrane characteristics and a decreased ability to metastasize, and DHA treatment exerted marked antimetastatic activity associated with pronounced change in the fatty acid component of tumours.

Fat Intake and Risk of Squamous Cell Carcinoma of the Skin

More studies are clearly needed to elucidate the function of dietary fatty acids so that recommendations can be made to alter the human diet for cancer prevention, particularly in light of the increasing incidence of SCC of the skin.