Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface.

@article{Zackular2015NutritionalIS,
  title={Nutritional Immunity: S100 Proteins at the Host-Pathogen Interface.},
  author={Joseph P. Zackular and Walter J Chazin and Eric P Skaar},
  journal={The Journal of biological chemistry},
  year={2015},
  volume={290 31},
  pages={18991-8}
}
The S100 family of EF-hand calcium (Ca(2+))-binding proteins is essential for a wide range of cellular functions. During infection, certain S100 proteins act as damage-associated molecular patterns (DAMPs) and interact with pattern recognition receptors to modulate inflammatory responses. In addition, these inflammatory S100 proteins have potent antimicrobial properties and are essential components of the immune response to invading pathogens. In this review, we focus on S100 proteins that… CONTINUE READING
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