Nutritional Aspects of Spermidine.

  title={Nutritional Aspects of Spermidine.},
  author={Frank Madeo and Sebastian J. Hofer and Tobias Pendl and Maria Anna Bauer and Tobias Eisenberg and Didac Carmona-Gutierrez and Guido Kroemer},
  journal={Annual review of nutrition},
Natural polyamines (spermidine and spermine) are small, positively charged molecules that are ubiquitously found within organisms and cells. They exert numerous (intra)cellular functions and have been implicated to protect against several age-related diseases. Although polyamine levels decline in a complex age-dependent, tissue-, and cell type-specific manner, they are maintained in healthy nonagenarians and centenarians. Increased polyamine levels, including through enhanced dietary intake… 

Unique Chemistry, Intake, and Metabolism of Polyamines in the Central Nervous System (CNS) and Its Body

The present review provides a novel and complete scheme for the biosynthesis of Pas, including glycine, glutamate, proline and others as PA precursors, and provides a hypothesis that the agmatine pathway may rescue putrescine production when ODC knockout seems to be lethal.

A comprehensive review of spermidine: Safety, health effects, absorption and metabolism, food materials evaluation, physical and chemical processing, and bioprocessing.

Advances in food processing were highlighted, and the core metabolic pathways, key gene targets, and efficient metabolic engineering strategies involved in the biosynthesis of spermidine and its precursors were discussed.

A systematic exploration reveals the potential of spermidine for hypopigmentation treatment through the stabilization of melanogenesis-associated proteins

The role of SPD in melanogenesis was investigated, showing potential as a pigmenting agent and a potential natural product to alleviate hypopigmentation.

Spermidine Ameliorates Nonalcoholic Steatohepatitis through Thyroid Hormone-Responsive Protein Signaling and the Gut Microbiota-Mediated Metabolism of Bile Acids.

  • Y. NiYating Hu Z. Fu
  • Biology, Medicine
    Journal of agricultural and food chemistry
  • 2022
Spermidine ameliorates NASH partly through the THRSP signaling and the gut microbiota-mediated metabolism of BAs, suggesting that sperMidine might be a viable therapy for NASH.

Oral administration of Akkermansia muciniphila elevates systemic antiaging and anticancer metabolites

Investigating the time-dependent effects of oral administration of Akk and other bacteria to mice on the metabolome of the ileum, colon, liver and blood plasma found that pasteurized Akk (Akk-past) was more efficient than live Akk in elevating the intestinal concentrations of polyamines, short-chain fatty acids, 2-hydroxybutyrate, as well multiple bile acids, which also increased in the circulation.

Spermidine protects against acute kidney injury by modulating macrophage NLRP3 inflammasome activation and mitochondrial respiration in an eIF5A hypusination-related pathway

This study identifies spermidine as a promising pharmacologic approach to prevent AKI and shows that eukaryotic initiation factor 5A (eIF5A) hypusination plays an important role in regulating macrophage bioactivity.

Elevation of Serum Spermidine in Obese Patients: Results from a Cross-Sectional and Follow-Up Study

Serum spermidine was positively associated with increased odds of obesity in the cross-sectional study but reduced odds of an increase in BMI in the follow-up study among Chinese adults.

Caloric Restriction Mimetics in Nutrition and Clinical Trials

Dietary sources, availability and intake levels of dietary Caloric Restriction Mimetics (CRMs), and a summary of their effects in clinical trials are discussed.

Circulating acetylated polyamines correlate with Covid-19 severity in cancer patients

The present work supports the contention that acetylated polyamines are associated with severe Covid-19, both in the general population and in patients with malignant disease.