Nutrition for the ageing brain: Towards evidence for an optimal diet

Abstract

As people age they become increasingly susceptible to chronic and extremely debilitating brain diseases. The precise cause of the neuronal degeneration underlying these disorders, and indeed normal brain ageing remains however elusive. Considering the limits of existing preventive methods, there is a desire to develop effective and safe strategies. Growing preclinical and clinical research in healthy individuals or at the early stage of cognitive decline has demonstrated the beneficial impact of nutrition on cognitive functions. The present review is the most recent in a series produced by the Nutrition and Mental Performance Task Force under the auspice of the International Life Sciences Institute Europe (ILSI Europe). The latest scientific advances specific to how dietary nutrients and non-nutrient may affect cognitive ageing are presented. Furthermore, several key points related to mechanisms contributing to brain ageing, pathological conditions affecting brain function, and brain biomarkers are also discussed. Overall, findings are inconsistent and fragmented and more research is warranted to determine the underlying mechanisms and to establish dose-response relationships for optimal brain maintenance in different population subgroups. Such approaches are likely to provide the necessary evidence to develop research portfolios that will inform about new dietary recommendations on how to prevent cognitive decline.

DOI: 10.1016/j.arr.2016.09.010

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@article{Vauzour2017NutritionFT, title={Nutrition for the ageing brain: Towards evidence for an optimal diet}, author={David Vauzour and Mar{\'i}a Camprub{\'i}-Robles and Sophie Miquel-Kergoat and Cristina Andres-Lacueva and Di{\'a}na B{\'a}n{\'a}ti and Pascale Barberger-Gateau and Gene L. Bowman and Laura Caberlotto and Robert Clarke and Eef Hogervorst and Amanda J Kiliaan and Ugo Lucca and Claudine Manach and Anne-Marie Minihane and Ellen Siobhan Mitchell and Robert Perneczky and Hugh Perry and Anne Marie Roussel and Jeroen Schuermans and John W. C. Sijben and Jeremy P. E. Spencer and Sandrine Thuret and Ondine van de Rest and Maurits F. J. Vandewoude and Keith A Wesnes and Robert J. Williams and Robin S. B. Williams and Maria Rosana Ramirez}, journal={Ageing Research Reviews}, year={2017}, volume={35}, pages={222-240} }