Nutrition and the insulin-like growth factor system

  title={Nutrition and the insulin-like growth factor system},
  author={Concepci{\'o}n F. Est{\'i}variz and Thomas R. Ziegler},
Nutritional status is a key regulator of the circulating and tissue insulin-like growth factor (IGF) system. IGF-I mRNA and protein levels decrease in tissues such as liver and intestine with fasting and are restored with refeeding. Additional studies suggest that the level of protein and calorie intake independently regulate plasma IGF-I concentrations in man. The level of nutrition effects the biological actions of recombinant growth hormone (GH) and IGF-I administration in humans. Limited… CONTINUE READING