Nutrition and the endothelium

  title={Nutrition and the endothelium},
  author={Esther L{\'o}pez-Garc{\'i}a and Frank B. Hu},
  journal={Current Diabetes Reports},
Growing evidence suggests that dietary factors play an important role in modulating endothelial function. Epidemiologic and clinical studies have related intake of α-linolenic acid and long-chain n-3 fatty acids to lower plasma concentrations of inflammatory cytokines and endothelial adhesion molecules, both of which are considered markers of endothelial dysfunction. In contrast, trans fatty acid intake and a higher dietary glycemic load have been associated with increased plasma concentrations… 
Diet and endothelial function: from individual components to dietary patterns
The currently available evidence supports beneficial effects of various dietary compounds on endothelial function, however, in order to obtain strong evidence for relevant health effects that can be used for specific dietary recommendations, more long-term studies using well characterized diets/supplements in a large number of individuals are needed.
Nuts, hypertension and endothelial function.
Dietary micronutrients intake and plasma fibrinogen levels in the general adult population
Although dietary intakes of vitamin E, magnesium and iron were inversely associated with fibrinogen levels, clinical implications of these findings are uncertain since these results were of very small magnitude and mostly explained by intake levels of other nutrients.
Chronic hyperglicemia and nitric oxide bioavailability play a pivotal role in pro-atherogenic vascular modifications
The recent data indicate that, in vivo, chronic hyperglycemia might induce an increased number of vSMC proliferative clones which persist in culture and are associated with increased eNOS expression and activity and may provide new insight on the mechanisms responsible for accelerated atherosclerosis in diabetes.
Dietary factors, Mediterranean diet and erectile dysfunction.
The adoption of a Mediterranean diet is associated with an improvement of erectile dysfunction and was more effective than a control diet in ameliorating ED or restoring absent ED in people with obesity or metabolic syndrome.
Association of dietary patterns with albuminuria and kidney function decline in older white women: a subgroup analysis from the Nurses' Health Study.
A Western dietary pattern is associated with a significantly increased odds of microalbuminuria and rapid kidney function decrease, whereas a DASH-style dietary pattern may be protective against rapid eGFR decline.
Association between dietary inflammatory index and kidney function in elderly population
The findings suggest that the DII score is not associated with serum hs-CRP and kidney function markers in elderly people.
DASH (Dietary Approaches to Stop Hypertension) Diet and Risk of Subsequent Kidney Disease.
  • C. Rebholz, D. Crews, J. Coresh
  • Medicine
    American journal of kidney diseases : the official journal of the National Kidney Foundation
  • 2016
Consuming a DASH-style diet was associated with lower risk for kidney disease independent of demographic characteristics, established kidney risk factors, and baseline kidney function.
Dietary factors in erectile dysfunction
The results of the present study show that dietary factors may be important in the development of ED: adoption of healthy diets would hopefully help preventing ED.


Major dietary patterns are related to plasma concentrations of markers of inflammation and endothelial dysfunction.
Because endothelial dysfunction is an early step in the development of atherosclerosis, this study suggests a mechanism for the role of dietary patterns in the pathogenesis of cardiovascular disease.
Dietary modulation of endothelial function: implications for cardiovascular disease.
  • A. A. Brown, F. Hu
  • Medicine, Biology
    The American journal of clinical nutrition
  • 2001
Clinical and experimental evidence regarding the role of n-3 fatty acids, antioxidant vitamins, folic acid, and L-arginine appear to have beneficial effects on vascular endothelial function and their potential to prevent cardiovascular disease are reviewed.
Consumption of trans fatty acids is related to plasma biomarkers of inflammation and endothelial dysfunction.
It is suggested that higher intake of trans fatty acids could adversely affect endothelial function, which might partially explain why the positive relation between trans fat and cardiovascular risk is greater than one would predict based solely on its adverse effects on lipids.
The postprandial effect of components of the Mediterranean diet on endothelial function.
Mediterranean and Low-Fat Diets Improve Endothelial Function in Hypercholesterolemic Men
The aim was to investigate endothelial function after substituting each of these potentially cardioprotective diets for a saturated fatenriched diet in hypercholesterolemic patients.
Consumption of (n-3) fatty acids is related to plasma biomarkers of inflammation and endothelial activation in women.
It is suggested that dietary (n-3) fatty acids are associated with levels of these biomarkers reflecting lower levels of inflammation and endothelial activation, which might explain in part the effect of these fatty acids in preventing cardiovascular disease.
Dietary intake of trans fatty acids and systemic inflammation in women.
TFA intake is positively associated with markers of systemic inflammation in women, and adjustment for serum lipid concentrations partly attenuated these associations, which suggests that they may be partly mediated by effects of TFAs on serum lipids.
Association between dietary patterns and plasma biomarkers of obesity and cardiovascular disease risk.
Major dietary patterns are predictors of plasma biomarkers of CVD and obesity risk, suggesting that the effect of overall diet on CVD risk may be mediated through these biomarkers.
Fatty acid modulation of endothelial activation.
Consumption of the n-3 fatty acid docosahexaenoic acid (DHA) reduced endothelial expression of vascular cell adhesion molecule 1 (VCAM-1) and reduced the adhesion of human monocytes and monocytic U937 cells to cytokine-stimulated endothelial cells, indicating a pretranslational effect.
Habitual Dietary Intake of n-3 and n-6 Fatty Acids in Relation to Inflammatory Markers Among US Men and Women
It is suggested that n-6 fatty acids do not inhibit the antiinflammatory effects of n-3 fatty acids and that the combination of both types of fatty acids is associated with the lowest levels of inflammation.