Corpus ID: 119083561

Nutrition and Cancer Fisetin Inhibits the Activities of Cyclin-Dependent Kinases Leading to Cell Cycle Arrest in HT-29 Human Colon Cancer Cells 1

  title={Nutrition and Cancer Fisetin Inhibits the Activities of Cyclin-Dependent Kinases Leading to Cell Cycle Arrest in HT-29 Human Colon Cancer Cells 1},
  author={Xianghuai Lu and Jae In Jung and Han Jin Cho and Do Young Lim and Hyun Sook Lee and Hyang Sook Chun and Dae Young Kwon and Jung Han Yoon Park},
Fisetin, a natural flavonol present in edible vegetables, fruits, and wine, was reported to exert anticarcinogenic effects. The objective of the current study was to examine the effect of fisetin on the cell cycle progression of the human colon cancer cell line HT-29. HT-29 cells were cultured in serum-free medium with 0, 20, 40, or 60 mol/L fisetin. Fisetin dose dependently inhibited both cell growth and DNA synthesis (P 0.05), with a 79 1% decrease in cell number observed 72 h after the… Expand

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