Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging?

@article{Jennings2000NutritionOD,
  title={Nutrition, oxidative damage, telomere shortening, and cellular senescence: individual or connected agents of aging?},
  author={Bridget J Jennings and Susan E Ozanne and Charles Nicholas Hales},
  journal={Molecular genetics and metabolism},
  year={2000},
  volume={71 1-2},
  pages={32-42}
}
There is substantial and long-standing literature linking the level of general nutrition to longevity. Reducing nutrition below the amount needed to sustain maximum growth increases longevity in a wide range of organisms. Oxidative damage has been shown to be a major feature of the aging process. Telomere shortening is now well established as a key process regulating cell senescence in vitro. There is some evidence that the same process may be important for aging in vivo. Very recently it has… CONTINUE READING