Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis

@article{Bern2014NutrigeneticsAN,
  title={Nutrigenetics and Nutrigenomics Insights into Diabetes Etiopathogenesis},
  author={G. Bern{\'a} and M. Oliveras-L{\'o}pez and E. Jurado-Ru{\'i}z and J. Tejedo and F. Bedoya and B. Soria and F. Mart{\'i}n},
  journal={Nutrients},
  year={2014},
  volume={6},
  pages={5338 - 5369}
}
Diabetes mellitus (DM) is considered a global pandemic, and the incidence of DM continues to grow worldwide. Nutrients and dietary patterns are central issues in the prevention, development and treatment of this disease. The pathogenesis of DM is not completely understood, but nutrient-gene interactions at different levels, genetic predisposition and dietary factors appear to be involved. Nutritional genomics studies generally focus on dietary patterns according to genetic variations, the role… Expand
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References

SHOWING 1-10 OF 178 REFERENCES
Application of nutrigenomic concepts to Type 2 diabetes mellitus.
TLDR
Key nutrigenomic concepts that help explain aspects of the development and complexity of T2DM are reviewed. Expand
Nutrigenetics and Metabolic Disease: Current Status and Implications for Personalised Nutrition
TLDR
This review presents the current state of the art in nutrigenetic research illustrating the significance of gene-nutrient interactions in the context of metabolic disease. Expand
Nutrigenetics: Bridging Two Worlds to Understand Type 2 Diabetes
TLDR
Evidence on the dietary environment and genetics as risk factors for T2DM is presented and bridging the 2 disciplines is highlighted and some key gene-nutrient interactions are highlighted. Expand
Nutrigenomics in Cardiovascular Medicine
TLDR
This review discusses these aspects and summarizes the literature pertaining to gene-diet interactions related to intermediate and final CVD phenotypes, as well as identifying candidate genes through the classic approach based on the protein function and through the recent genome-wide association studies. Expand
Complexity of type 2 diabetes mellitus data sets emerging from nutrigenomic research: a case for dimensionality reduction?
TLDR
Type 2 diabetes mellitus (T2DM) is used as an illustration of the challenges in studying complex phenotypes with nutrigenomics concepts and approaches. Expand
A Database of Gene-Environment Interactions Pertaining to Blood Lipid Traits, Cardiovascular Disease and Type 2 Diabetes.
TLDR
This database will serve as an important resource to researchers in genetics and nutrition in order to gain an understanding of which points in the human genome are sensitive to variations in diet, physical activity and alcohol use, among other lifestyle choices. Expand
Lifestyle and genetics in obesity and type 2 diabetes.
  • T. Temelkova-Kurktschiev, T. Stefanov
  • Medicine
  • Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association
  • 2012
TLDR
Gene-lifestyle interaction studies suggest that genetic susceptibility to obesity and type 2 diabetes may be partially or totally kept under control by healthy lifestyle or lifestyle modification and that lifestyle determines whether an individual is likely to develop the disease. Expand
Gene-environment interactions in the development of type 2 diabetes: recent progress and continuing challenges.
TLDR
It is suggested that the adverse effect of several T2D loci may be abolished or at least attenuated by higher physical activity levels or healthy lifestyle, whereas low physical activity and dietary factors characterizing a Western dietary pattern may augment it. Expand
Recent advances in understanding the anti-diabetic actions of dietary flavonoids.
TLDR
Recent findings on the anti-diabetic effects of dietary flavonoids, including flavan-3-ols, flavanones, flavonols, anthocyanidins, flavones and isoflavones are highlighted, with particular emphasis on the studies that investigated the cellular and molecular mechanisms involved in the beneficial effects of the compounds. Expand
The Emerging Role of MicroRNAs in the Regulation of Gene Expression by Nutrients
TLDR
The evidence regarding the changes in miRNA expression that are caused by diets with a deficiency or augmented intake of nutrients such as amino acids, carbohydrates, fatty acids, vitamins, and phytochemicals is summarized. Expand
...
1
2
3
4
5
...