Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis.

  title={Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis.},
  author={Aksam J. Merched and Charles N Serhan and Lawrence Chan},
  journal={Journal of nutrigenetics and nutrigenomics},
  volume={4 1},
BACKGROUND/AIM Pro-resolving and anti-inflammatory mediator products of murine 12/15-lipoxygenase (LOX) exhibit potent actions on vascular inflammation and protect against the progression of atherosclerosis. The present study was designed to determine whether augmenting dietary lipids modulates the body's endogenous anti-inflammatory pro-resolving mechanisms and promotes atherosclerosis. METHODS/RESULTS We investigated the biometabolic consequences of variations in lipid mediator biosynthesis… CONTINUE READING
15 Citations
27 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 15 extracted citations


Publications referenced by this paper.
Showing 1-10 of 27 references

Nutrigenomics 2011;4:12–24 DOI: 10.1159/000326890 Merched et al.: Western Diet Disrupts Inflammatory Homeostasis

  • J Nutrigenet
  • 2011

damentals of Inflammation

  • AJ Merched, E Williams, L Chan
  • 2010

Similar Papers

Loading similar papers…