Nutrients and growth factors in mTORC1 activation.

@article{Efeyan2013NutrientsAG,
  title={Nutrients and growth factors in mTORC1 activation.},
  author={Alejo Efeyan and David M. Sabatini},
  journal={Biochemical Society transactions},
  year={2013},
  volume={41 4},
  pages={902-5}
}
Growth factors and nutrients regulate the mTORC1 [mammalian (or mechanistic) target of rapamycin complex 1] by different mechanisms. The players that link growth factors and mTORC1 activation have been known for several years and mouse models have validated its relevance for human physiology and disease. In contrast with the picture for growth factor signalling, the means by which nutrient availability leads to mTORC1 activation have remained elusive until recently, with the discovery of the… CONTINUE READING

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