Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation

@inproceedings{Sodi2018NutrientSO,
  title={Nutrient sensor O-GlcNAc transferase controls cancer lipid metabolism via SREBP-1 regulation},
  author={Valerie L. Sodi and Zachary A. Bacigalupa and Christina M. Ferrer and Joyce V. Lee and Wiktoria A. Gocal and Dimpi Mukhopadhyay and Kathryn E Wellen and Mircea Ivan and Mauricio J. Reginato},
  booktitle={Oncogene},
  year={2018}
}
Elevated O-GlcNAcylation is associated with disease states such as diabetes and cancer. O-GlcNAc transferase (OGT) is elevated in multiple cancers and inhibition of this enzyme genetically or pharmacologically inhibits oncogenesis. Here we show that O-GlcNAcylation modulates lipid metabolism in cancer cells. OGT regulates expression of the master lipid regulator the transcription factor sterol regulatory element binding protein 1 (SREBP-1) and its transcriptional targets both in cancer and… CONTINUE READING
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