Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis

@inproceedings{Gohil2010NutrientsensitizedSF,
  title={Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis},
  author={Vishal M Gohil and Sunil A. Sheth and Roland Nilsson and Andrew P. Wojtovich and Jeong Hyun Lee and Fabiana Perocchi and William Chen and Clary B Clish and Cenk Ayata and Paul S Brookes and Vamsi K. Mootha},
  year={2010}
}
Virtually all cells exhibit metabolic flexibility and are capable of shifting their reliance on glycolysis relative to mitochondrial respiration. Such shifts can occur at different timescales through a variety of mechanisms, allowing cells to cope with prevailing nutrient availability or energetic demands. There is mounting evidence of the therapeutic potential of targeting such shifts. For example, many cancer cells rely on aerobic glycolysis (the Warburg effect)1, and a recent study has shown… CONTINUE READING