Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.

@article{Liu2014NutrientSB,
  title={Nutrient sensing by the mitochondrial transcription machinery dictates oxidative phosphorylation.},
  author={Lijun Leo Liu and Minwoo Nam and Wei Fan and Thomas E. Akie and David C. Hoaglin and Guangping Gao and John F. Keaney and Marcus P. Cooper},
  journal={The Journal of clinical investigation},
  year={2014},
  volume={124 2},
  pages={768-84}
}
Sirtuin 3 (SIRT3), an important regulator of energy metabolism and lipid oxidation, is induced in fasted liver mitochondria and implicated in metabolic syndrome. In fasted liver, SIRT3-mediated increases in substrate flux depend on oxidative phosphorylation (OXPHOS), but precisely how OXPHOS meets the challenge of increased substrate oxidation in fasted… CONTINUE READING