Nutrient regulation of insulin gene expression.

  title={Nutrient regulation of insulin gene expression.},
  author={Kevin Docherty and A R Clark},
  journal={FASEB journal : official publication of the Federation of American Societies for Experimental Biology},
  volume={8 1},
The beta cell of the islets of Langerhans contributes along with other factors to glucose homeostasis by sensing changes in the plasma glucose concentrations and adjusting the rate of insulin production and release. Over short periods of time, insulin production is controlled principally through translation of pre-existing mRNA. Over longer periods, insulin mRNA levels are modulated through effects on the rate of transcription of the insulin gene, and also through changes in the rate of decay… CONTINUE READING


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