Nutrient-driven O-GlcNAc cycling impacts neurodevelopmental timing and metabolism

  title={Nutrient-driven O-GlcNAc cycling impacts neurodevelopmental timing and metabolism},
  author={Stephanie OLIVIER-VAN STICHELEN and Peng Wang and Marcy Comly and Dona C. Love and John A Hanover},
Nutrient-driven O-GlcNAcylation is strikingly abundant in the brain and has been linked to development and neurodegenerative disease. We selectively targeted the O-GlcNAcase (Oga) gene in the mouse brain to define the role of O-GlcNAc cycling in the central nervous system. The brain-knockout animals exhibited dramatically increased brain O-GlcNAc levels and pleiotropic phenotypes including early onset obesity, growth defects, and metabolic dysregulation. Anatomical defects in the Oga knockout… CONTINUE READING