Nutrient depletion may trigger the Yersinia pestis OmpR‐EnvZ regulatory system to promote flea‐borne plague transmission

  title={Nutrient depletion may trigger the Yersinia pestis OmpR‐EnvZ regulatory system to promote flea‐borne plague transmission},
  author={S{\'e}bastien Bontemps-Gallo and Marion Fernandez and Am{\'e}lie Dewitte and Etienne Rapha{\"e}l and F. Gherardini and Pradel Elizabeth and L. Koch and F. Biot and A. Reboul and F. Sebbane},
  journal={Molecular Microbiology},
The flea’s lumen gut is a poorly documented environment where the agent of flea‐borne plague, Yersinia pestis, must replicate to produce a transmissible infection. Here, we report that both the acidic pH and osmolarity of the lumen’s contents display simple harmonic oscillations with different periods. Since an acidic pH and osmolarity are two of three known stimuli of the OmpR‐EnvZ two‐component system in bacteria, we investigated the role and function of this Y. pestis system in fleas. By… Expand
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Transmission of Yersinia pestis from an infectious biofilm in the flea vector.
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Phenotypic and transcriptional analysis of the osmotic regulator OmpR in Yersinia pestis
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OmpR positively regulates urease expression to enhance acid survival of Yersinia pseudotuberculosis.
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