Nutrient-dependent regulation of autophagy through the target of rapamycin pathway.

@article{Chang2009NutrientdependentRO,
  title={Nutrient-dependent regulation of autophagy through the target of rapamycin pathway.},
  author={Yu-Yun Chang and G{\'a}bor D. Juh{\'a}sz and Pankuri Goraksha-Hicks and Andrew M. Arsham and Daniel R. Mallin and Laura K. Muller and Thomas P Neufeld},
  journal={Biochemical Society transactions},
  year={2009},
  volume={37 Pt 1},
  pages={
          232-6
        }
}
In response to nutrient deficiency, eukaryotic cells activate macroautophagy, a degradative process in which proteins, organelles and cytoplasm are engulfed within unique vesicles called autophagosomes. Fusion of these vesicles with the endolysosomal compartment leads to breakdown of the sequestered material into amino acids and other simple molecules, which can be used as nutrient sources during periods of starvation. This process is driven by a group of autophagy-related (Atg) proteins, and… CONTINUE READING

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