Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes

  title={Nutrient-Sensing Mechanisms in the Gut as Therapeutic Targets for Diabetes},
  author={Danna M. Breen and Brittany A. Rasmussen and Cl{\'e}mence D. C{\^o}t{\'e} and Vivienne Margaret Jackson and Tony K. T. Lam},
The small intestine is traditionally viewed as an organ that mediates nutrient digestion and absorption. This view has recently been revised owing to the ability of the duodenum to sense nutrient influx and trigger negative feedback loops to inhibit glucose production and food intake to maintain metabolic homeostasis. Further, duodenal nutrient-sensing defects are acquired in diabetes and obesity, leading to increased glucose production. In contrast, jejunal nutrient sensing inhibits glucose… CONTINUE READING
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