Nutrient‐driven O‐GlcNAc in proteostasis and neurodegeneration

  title={Nutrient‐driven O‐GlcNAc in proteostasis and neurodegeneration},
  author={Ilhan Akan and St{\'e}phanie Olivier-Van Stichelen and Michelle R. Bond and John A. Hanover},
  journal={Journal of Neurochemistry},
Proteostasis is essential in the mammalian brain where post-mitotic cells must function for decades to maintain synaptic contacts and memory. The brain is dependent on glucose and other metabolites for proper function and is spared from metabolic deficits even during starvation. In this review, we outline how the nutrient-sensitive nucleocytoplasmic post-translational modification O-linked N-acetylglucosamine (O-GlcNAc) regulates protein homeostasis. The O-GlcNAc modification is highly abundant… CONTINUE READING
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