Nutraceuticals in the treatment of Obsessive Compulsive Disorder (OCD): A review of mechanistic and clinical evidence

@article{Camfield2011NutraceuticalsIT,
  title={Nutraceuticals in the treatment of Obsessive Compulsive Disorder (OCD): A review of mechanistic and clinical evidence},
  author={David Camfield and Jerome Sarris and Michael Berk},
  journal={Progress in Neuro-Psychopharmacology and Biological Psychiatry},
  year={2011},
  volume={35},
  pages={887-895}
}
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Present preclinical studies indicate that monoamine pathway modulation (in particular serotonin reuptake inhibition) may be the most important anti-OCD mechanism among the studied natural compounds.
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  • 2015
TLDR
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A significant proportion of patients with obsessive-compulsive disorder (OCD) do not achieve remission with current treatments, indicating the need for innovations in psychopharmacology for the disorder.
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TLDR
The effectiveness of herbal and nutritional supplements in the treatment of OCD should be supported with more conclusive evidence.
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The effectiveness of herbal and nutritional supplements in the treatment of OCD should be supported with more conclusive evidence.
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TLDR
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N-Acetylcysteine for the Treatment of Psychiatric Disorders: A Review of Current Evidence
TLDR
Current evidence supports N-acetylcysteine use as an adjunctive therapy clinically for psychiatric conditions, administered concomitantly with existing medications, with a recommended dosage between 2000 and 2400 mg/day.
Obsessive-Compulsive Disorder: Diagnosis and Management with an Osteopathic Component
TLDR
The epidemiology of OCD, the DSM-5 criteria for OCD,The current OCD treatments, the osteopathic approach and how it pertains to OCD treatment, and lastly, OMT and its possible role in treating OCD are discussed.
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Obsessive-compulsive disorder (OCD) is a common psychiatric disorder and the tenth leading cause of disability in the world. The introduction of serotonin reuptake inhibitors (SRIs) in the 1980s
N-acetylcysteine augmentation in serotonin reuptake inhibitor refractory obsessive-compulsive disorder
TLDR
NAC augmentation was effective in treating SRI-refractory OCD in this single case and further research is warranted to investigate the use of NAC and other glutamate modulating agents in the treatment of OCD.
Inositol augmentation of serotonin reuptake inhibitors in treatment-refractory obsessive-compulsive disorder: an open trial.
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An updated literature review of the evidence supporting available strategies for the treatment of obsessive-compulsive disorder is presented, finding that selective serotonin reuptake inhibitors (SSRIs) remain the pharmacological treatment of choice for most patients and are associated with improved health-related quality of life.
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Quantitative review of the controlled treatment outcome literature for obsessive-compulsive disorder (OCD) showed that exposure with response prevention was highly effective in reducing OCD symptoms.
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