Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review.

Abstract

Chemotherapy induced peripheral neuropathy [CIPN] is a common significant and debilitating side effect resulting from the administration of neurotoxic chemotherapeutic agents. These pharmaco-chemotherapeutics can include taxanes, vinca alkaloids and others. Moderate to severe CIPN significantly decreases the quality of life and physical abilities of cancer patients and current pharmacotherapy for CIPN e.g. Amifostine and antidepressants have had limited efficacy and may themselves induce adverse side effects. To determine the potential use of nutraceuticals i.e. vitamin E, acetyl-L-carnitine, glutamine, glutathione, vitamin B6, omega-3 fatty acids, magnesium, calcium, alpha lipoic acid and n-acetyl cysteine as adjuvants in cancer treatments a systematic literature review was conducted. Revised clinical studies comprised of randomized clinical trials that investigated the anti-CIPN effect of nutraceuticals as the adjuvant intervention in patients administered chemotherapy. Twenty-four studies were assessed on methodological quality and limitations identified. Studies were mixed in their recommendations for nutraceuticals. Currently no agent has shown solid beneficial evidence to be recommended for the treatment or prophylaxis of CIPN. The standard of care for CIPN includes dose reduction and/or discontinuation of chemotherapy treatment. The management of CIPN remains an important challenge and future studies are warranted before recommendations for the use of supplements can be made.

DOI: 10.1016/j.clnu.2013.04.007

4 Figures and Tables

020406020132014201520162017
Citations per Year

139 Citations

Semantic Scholar estimates that this publication has 139 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Schloss2013NutraceuticalsAC, title={Nutraceuticals and chemotherapy induced peripheral neuropathy (CIPN): a systematic review.}, author={Janet M. Schloss and Maree Colosimo and Caroline Airey and Paul P. Masci and A. W. Linnane and Luis Vitetta}, journal={Clinical nutrition}, year={2013}, volume={32 6}, pages={888-93} }