Nutmeg intoxication in Texas, 1998–2004

@article{Forrester2005NutmegII,
  title={Nutmeg intoxication in Texas, 1998–2004},
  author={Mathias B. Forrester},
  journal={Human and Experimental Toxicology},
  year={2005},
  volume={24},
  pages={563 - 566}
}
  • M. Forrester
  • Published 2005
  • Medicine
  • Human and Experimental Toxicology
Nutmeg is a spice that contains volatile oils comprised of alkyl benzene derivatives (myristicin, elemicin, safrole, etc.), terpenes and myristic acid. Nutmeg has a long history of abuse. This study describes the nutmeg ingestion calls received by Texas poison centers from 1998 to 2004. There were 17 calls involving nutmeg ingestion, of which 64.7% involved intentional abuse. When abuse and non-abuse ingestions were compared, abuse ingestions were more likely to involve males (100 versus 66.7… Expand
The spice of life: An analysis of nutmeg exposures in California
TLDR
Although nutmeg exposure is uncommonly encountered, clinical effects from ingestion can be significant and can require medical intervention, and clinically significant effects were common, life-threatening toxicity and death did not occur in this series. Expand
Toxicity of Nutmeg (Myristicin): A Review
TLDR
A detailed review of myristicin is reported, which is responsible for hallucinogenic effects, which induced by the consumption of nutmeg due to its metabolism structure of 3-methoxy-4,5-methylendioxyamphetamine (MMDA), and its effects on health problems related to brain problem. Expand
Nutmeg Poisonings: A Retrospective Review of 10 Years Experience from the Illinois Poison Center, 2001–2011
TLDR
An unexpected percentage of unintentional exposures in juveniles under the age of 13, out of the total exposures to nutmeg, are shown in this study. Expand
Determination of myristicin in commonly spices applying SPE/GC.
  • A. Dawidowicz, M. Dybowski
  • Chemistry, Medicine
  • Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2012
TLDR
The presented analytical approach constitutes a substantial improvement on previously reported methods for myristicin analysis and seems to be the method of choice for determining the amount of the compound in spices containing nutmeg. Expand
Nutmeg overdose: Spice not so nice.
TLDR
Emergency personnel should be aware of nutmeg toxicity due to its ability to mimic many other neurological, cardiac and psychiatric conditions, and increased awareness of this issue can help minimize the risk of misdiagnosis. Expand
Abuse of Nutmeg (Myristica fragrans Houtt.): Studies on the Metabolism and the Toxicologic Detection of its Ingredients Elemicin, Myristicin, and Safrole in Rat and Human Urine Using Gas Chromatography/Mass Spectrometry
TLDR
Toxicologic detection of nutmeg abuse was possible by identification of the described metabolites of the EL, MY, and SA in urine applying the authors' systematic toxicologic analysis procedure after acid hydrolysis, liquid-liquid extraction of analytes, and microwave-assisted acetylation of extracted analytes. Expand
Hepatotoxicity of nutmeg: A pilot study based on metabolomics.
TLDR
It is reasonably speculates that nutmeg exposure may cause liver damage and affect liver function depending on the dose and duration of exposure. Expand
Adolescent Synthetic Cannabinoid Exposures Reported to Texas Poison Centers
TLDR
The pattern of exposures among patients younger than 20 years reported to Texas poison centers during January 2010 to June 2011 was similar to that observed among adults and the adolescents were more likely to involve inhalation. Expand
HPTLC Analysis of Myristicin and Safrole in Seed Powder of Myristica fragrans Houtt.
Nutmeg is abused because myristicin has psychotropic and hallucinogenic properties [5]. Human studies indicate that myristicin at a dose of 6–7 mg kg –1 body weight can have psychopharmacologicalExpand
Mass spectrometric investigation of intoxications with plant-derived psychoactive substances
TLDR
The results suggest a low occurrence of psychoactive plant use in Sweden, and a multi-component LC-MS/MS method for detection of ten plant-derived psychoactive substances in urine. Expand
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