Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation.

@article{Walsh2015Nutlin3DR,
  title={Nutlin-3 down-regulates retinoblastoma protein expression and inhibits muscle cell differentiation.},
  author={Erica M. Walsh and Mengmeng Niu and Johann S Bergholz and Zhi-xiong Xiao},
  journal={Biochemical and biophysical research communications},
  year={2015},
  volume={461 2},
  pages={293-9}
}
The p53 tumor suppressor gene plays a critical role in regulation of proliferation, cell death and differentiation. The MDM2 oncoprotein is a major negative regulator for p53 by binding to and targeting p53 for proteasome-mediated degradation. The small molecule inhibitor, nutlin-3, disrupts MDM2-p53 interaction resulting in stabilization and activation of p53 protein. We have previously shown that nutlin-3 activates p53, leading to MDM2 accumulation as concomitant of reduced retinoblastoma (Rb… CONTINUE READING
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