Nurse-like cells mediate ibrutinib resistance in chronic lymphocytic leukemia patients

@inproceedings{Boissard2015NurselikeCM,
  title={Nurse-like cells mediate ibrutinib resistance in chronic lymphocytic leukemia patients},
  author={F Boissard and J-J Fourni{\'e} and Anne Quillet-Mary and Lo{\"i}c Ysebaert and Mary Poupot},
  booktitle={Blood cancer journal},
  year={2015}
}
Chronic lymphocytic leukemia (CLL) is one of the most common B-cell malignancies in adults, characterized by an accumulation of monoclonal CD5+ mature B-cells in lymphoid tissues and peripheral blood (PB). Clonal expansion and invasive migration typically lead to CLL cell involvement in the lymph nodes (LNs), spleen and bone marrow (BM).1 Signaling from the B-cell antigen receptor regulates multiple cellular processes in CLL cells, such as proliferation, differentiation, apoptosis and cell… CONTINUE READING
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