Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism

@article{Sacchetti2001Nurr1ET,
  title={Nurr1 enhances transcription of the human dopamine transporter gene through a novel mechanism},
  author={Paola Sacchetti and Todd R. Mitchell and James G. Granneman and Michael J. Bannon},
  journal={Journal of Neurochemistry},
  year={2001},
  volume={76}
}
The importance of the nuclear receptor nurr1 for the appropriate development of mesencephalic dopamine‐synthesizing neurons has been clearly demonstrated through the targeted disruption of the nurr1 gene. The persistence of nurr1 expression in adult tissue suggests a possible role for this transcription factor in the maintenance, as well as development, of the dopaminergic phenotype. To address this issue, we analyzed the effects of nurr1 on the transcriptional expression of the human dopamine… 

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TLDR
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TLDR
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TLDR
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Requirements for Heterodimerization between the Orphan Nuclear Receptor Nurr1 and Retinoid X Receptors*

TLDR
It is shown that nurr1 acts as a gene activator independently of RXR and through an AF2-independent mechanism, and heterodimerization with RXR is isotype-specific, involves multiple domains in the C-terminal region of nurR1, and requires RXR binding to DNA.
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