Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity.

@article{Pols2008Nur77MH,
  title={Nur77 modulates hepatic lipid metabolism through suppression of SREBP1c activity.},
  author={Thijs W H Pols and Roelof Ottenhoff and Mariska H Vos and Johannes H. M. Levels and Paul H A Quax and Joost C M Meijers and H. Pannekoek and Albert K. Groen and Carlie J. M. de Vries},
  journal={Biochemical and biophysical research communications},
  year={2008},
  volume={366 4},
  pages={910-6}
}
NR4A nuclear receptors are induced in the liver upon fasting and regulate hepatic gluconeogenesis. Here, we studied the role of nuclear receptor Nur77 (NR4A1) in hepatic lipid metabolism. We generated mice expressing hepatic Nur77 using adenoviral vectors, and demonstrate that these mice exhibit a modulation of the plasma lipid profile and a reduction in… CONTINUE READING