Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover.

  title={Nur77 gene knockout alters dopamine neuron biochemical activity and dopamine turnover.},
  author={François Gilbert and Marc P. Morissette and Michel St-Hilaire and Brigitte Paquet and Claude Rouillard and Th{\'e}r{\`e}se Di Paolo and Daniel L{\'e}vesque},
  journal={Biological psychiatry},
  volume={60 6},
BACKGROUND Transcription factors of the Nur family (Nurr1, Nur77, and Nor-1) are orphan nuclear receptors closely associated with dopamine neurotransmission in the central nervous system. Nur77 expression is strongly modulated by antipsychotic and ant-parkinsonian drugs in dopaminoceptive brain areas. However, the role of Nur77 in dopamine neuron activity and turnover remains elusive. METHODS We compared various behavioral and biochemical parameters between Nur77 knockout -/- and wild-type… CONTINUE READING
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