Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma.

@article{Luciano2007Nur77CP,
  title={Nur77 converts phenotype of Bcl-B, an antiapoptotic protein expressed in plasma cells and myeloma.},
  author={Fr{\'e}d{\'e}ric Luciano and Maryla Krajewska and Paulina Ortiz-Rubio and Stan Stanislaw Krajewski and Dayong Zhai and Benjamin Faustin and J Bruey and B{\'e}atrice Bailly-Maitre and Alan Lichtenstein and Siva Kumar Kolluri and Arnold C. Satterthwait and Xiaokun Zhang and John C. Reed},
  journal={Blood},
  year={2007},
  volume={109 9},
  pages={3849-55}
}
Defects in apoptosis mechanisms play important roles in malignancy and autoimmunity. Orphan nuclear receptor Nur77/TR3 has been demonstrated to bind antiapoptotic protein Bcl-2 and convert it from a cytoprotective to a cytodestructive protein, representing a phenotypic conversion mechanism. Of the 6 antiapoptotic human Bcl-2 family members, we found that Nur77/TR3 binds strongest to Bcl-B, showing selective reactivity with Bcl-B, Bcl-2, and Bfl-1 but not Bcl-X(L), Mcl-1, or Bcl-W. Nur77… CONTINUE READING

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