Nup98-Homeodomain Fusions Interact with Endogenous Nup98 during Interphase and Localize to Kinetochores and Chromosome Arms during Mitosis

Abstract

Chromosomal translocations involving the Nup98 gene are implicated in leukemias, especially acute myelogenous leukemia. These translocations generate chimeric fusion proteins, all of which have in common the N-terminal half of Nup98, which contains the nucleoporin FG/GLFG repeat motifs. The homeodomain group of Nup98 fusion proteins retain the C-terminus of… (More)
DOI: 10.1091/mbc.E09-07-0561

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Cite this paper

@inproceedings{Xu2010Nup98HomeodomainFI, title={Nup98-Homeodomain Fusions Interact with Endogenous Nup98 during Interphase and Localize to Kinetochores and Chromosome Arms during Mitosis}, author={Songli Xu and Maureen A. Powers}, booktitle={Molecular biology of the cell}, year={2010} }