Nup53 is required for nuclear envelope and nuclear pore complex assembly.

@article{HawrylukGara2008Nup53IR,
  title={Nup53 is required for nuclear envelope and nuclear pore complex assembly.},
  author={Lisa A Hawryluk-Gara and Melpomeni Platani and Rachel A Santarella and Richard W Wozniak and Iain W Mattaj},
  journal={Molecular biology of the cell},
  year={2008},
  volume={19 4},
  pages={
          1753-62
        }
}
Transport across the nuclear envelope (NE) is mediated by nuclear pore complexes (NPCs). These structures are composed of various subcomplexes of proteins that are each present in multiple copies and together establish the eightfold symmetry of the NPC. One evolutionarily conserved subcomplex of the NPC contains the nucleoporins Nup53 and Nup155. Using truncation analysis, we have defined regions of Nup53 that bind to neighboring nucleoporins as well as those domains that target Nup53 to the… CONTINUE READING