Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.

@article{Mackay2017Nup153AN,
  title={Nup153 and Nup50 promote recruitment of 53BP1 to DNA repair foci by antagonizing BRCA1-dependent events.},
  author={Douglas R Mackay and Amanda C Howa and Theresa L Werner and Katharine S. Ullman},
  journal={Journal of cell science},
  year={2017},
  volume={130 19},
  pages={3347-3359}
}
DNA double-strand breaks are typically repaired through either the high-fidelity process of homologous recombination (HR), in which BRCA1 plays a key role, or the more error-prone process of non-homologous end joining (NHEJ), which relies on 53BP1. The balance between NHEJ and HR depends, in part, on whether 53BP1 predominates in binding to damage sites, where it protects the DNA ends from resection. The nucleoporin Nup153 has been implicated in the DNA damage response, attributed to a role in… CONTINUE READING
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